Many varied conditions can lead to fatigue. However, at the core is mitochondrial dysfunction.
The mitochondria are the energy power houses of the cells. These wizards require healthy and intact membranes with which to generate energy through a process called electron transport. In healthy cells, the inner mitochondrial membranes contain as nearly impermeable membranes, which protect the cell from early death. If the membrane becomes permeable, this signals a programmed death for the cell. As cells age, their ability to create strong electron output (energy) can become diminished–causing oxidative reactions, which lead to lower energy and fatigue.
fMitochondrial membrane permeability is greatly affected in viral and bacterial infections, metabolic diseases, Alzheimers, Parkinsons, ALS, heart disease, and dysbiosis (digestive) problems. When damaged, the mitochondrial membrane assists in releasing toxic proteins, which in turn trigger the formation of highly inflammatory molecules. So, ATP (energy) production diminishes, creating perceived fatigue.
How can we restore the cells’ mitochondrial membrane? Do read on!
Lipid replacement therapy (LRT) in the form of a stable oral supplement has shown extraordinary promise in studies. In fact, LRT and the B-vitamins together have shown to reduce an amino acid called Homocysteine, which when elevated by inflammation, increases one’s risk for depression, cardiovascular disease, stroke, cognitive loss, and lowered immunity. Studies show a 30-45% improvement in fatigued cancer patients and chronic fatigue patients. The clinical use of LRT has the potential to decrease aging of the mitochondria, diminish fatigue and depression, and improve gut ecology. The immune tolerance improves that and extends throughout the entire systems.
LRT is not just the dietary substitution of phospholipids, which is at the core of all cell membranes. It is the actual replacement for healthy new cell membrane. The major classes of phospholipids include phosphatidylcholine (PC,) phosphatidylethanolamine (PE,) phosphatidylinositol (PI,) phosphatidylserine (PS,) phosphatidic acid (PA,) plus phosphatidylglycerol (PG.) Take a look at the research by Allergy Research Group out of Alameda, California. The product to look for is a Glycophospholipid formulation with NADH and CoQ10. I like ATP by Researched Nutritionals.